Evaluation of the antihistamine effects of olopatadine and levocetirizine during a 24-h period: a double-blind, randomized, cross-over, placebo-controlled comparison in skin responses induced by histamine iontophoresis
| Autor: | Akina Ogawa, Tomohiro Takeo, Rui Tanaka, Chikatoshi Kasugai, Takashi Ando, Daisuke Watanabe, Yoichi Akita |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Histamine H1 Antagonists Non-Sedating medicine.medical_treatment Dermatology Pharmacology Placebo Levocetirizine chemistry.chemical_compound Young Adult Cognition Double-Blind Method Medicine Humans Olopatadine Hydrochloride Cross-Over Studies Iontophoresis business.industry Pruritus General Medicine Olopatadine Middle Aged Crossover study Cetirizine Healthy Volunteers chemistry Anesthesia Antihistamine Female Sleep Stages business Histamine Dibenzoxepins medicine.drug |
| Zdroj: | The Journal of dermatology. 40(12) |
| ISSN: | 1346-8138 |
| Popis: | The antihistamine effects of olopatadine and levocetirizine, in standard-dose application described in their information (5 mg twice a day for olopatadine; 5 mg once daily for levocetirizine), were examined from 11.5 to 24 h after application. The test was designed in a double-blind, randomized, cross-over, placebo-controlled study of 12 healthy volunteers on histamine-induced flare and wheal response using an iontophoresis technique. The suppressive effect of olopatadine on the wheals induced by a 0.1-mA histamine iontophoresis lasted for 24 h after dosing. Both drugs inhibited flare induced by histamine iontophoresis almost completely until 24 h after the first administration. Suppression of the 0.2-mA-induced wheal response by levocetirizine, taken once daily, decreased with time, although 0.1-mA-induced flare was almost completely suppressed by the drug. Olopatadine completely suppressed even the wheal response induced by a 0.2-mA histamine iontophoresis. Compared with the placebo, the two drugs significantly suppressed the subjective itching assessed by visual analog scale at all intervals. There were no significant differences in subjective drowsiness and objective cognitive function between drug- and placebo-treated subjects. These results demonstrate that olopatadine seems to be more potent than levocetirizine when administrated in a standard dose. In conclusion, mild to moderate urticaria could be controlled by standard application as described in their information. On the other hand, severe urticaria could be managed by a standard application of olopatadine, but levocetirizine may need an additional dose to control severe urticaria. |
| Databáze: | OpenAIRE |
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