Metformin and thyroid disease
| Autor: | Guofang Chen, Chao Liu, Shuhang Xu, Xianghui Meng, Michael Derwahl |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Thyroid nodules
Thyroid Hormones endocrine system medicine.medical_specialty Goiter endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Hyperinsulinemia Humans Hypoglycemic Agents Medicine Thyroid cancer business.industry Thyroid disease Thyroid medicine.disease Thyroid Diseases Metformin medicine.anatomical_structure Pituitary Gland 030220 oncology & carcinogenesis business medicine.drug Hormone |
| Zdroj: | Journal of Endocrinology. 233:R43-R51 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1530/joe-16-0450 |
| Popis: | An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Multiple studies in vitro and in vivo have demonstrated that metformin can inhibit the growth of thyroid cells and different types of thyroid cancer cells by affecting the insulin/IGF1 and mTOR pathways. Besides, metformin treatment was associated with a decrease in the levels of serum thyroid-stimulating hormone (TSH) in diabetic patients possibly by enhancing the effects of thyroid hormones in the pituitary and activating the adenosine monophosphate-activated protein kinase (AMPK). Based on this evidence, metformin appears to be a promising therapeutic tool in patients with thyroid disease. More clinical studies are necessary to evaluate the clinical significance of metformin for the treatment of thyroid diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|