Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus in Young Men: Results of a Randomized Controlled Trial Conducted in Orange Farm, South Africa
| Autor: | Joelle Sobngwi-Tambekou, Pascale Lissouba, Marthi Nieuwoudt, Ewalde Cutler, Bertran Auvert, Dirk Taljaard, Adrian Puren |
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| Přispěvatelé: | Hôpital Ambroise Paré [AP-HP], Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Institute for Communicable Disease, Progressus, Kaniewski, Nadine, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2009 |
| Předmět: |
Male
MESH: Sexual Behavior Gonorrhea Prevalence HIV Infections MESH: Papillomavirus Infections MESH: Risk Assessment law.invention South Africa 0302 clinical medicine MESH: South Africa Randomized controlled trial Risk Factors MESH: Risk Factors law Immunology and Allergy 030212 general & internal medicine Young adult education.field_of_study MESH: HIV Infections 3. Good health MESH: Urethra Infectious Diseases MESH: Neisseria gonorrhoeae MESH: Young Adult 030220 oncology & carcinogenesis Marital status MESH: Circumcision Male medicine.medical_specialty Adolescent Sexual Behavior Population Lower risk Risk Assessment Young Adult 03 medical and health sciences Urethra Condom medicine Humans education MESH: Prevalence MESH: Adolescent Gynecology MESH: Humans business.industry Papillomavirus Infections MESH: Gonorrhea medicine.disease Neisseria gonorrhoeae MESH: Male Circumcision Male [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Demography |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2009, 199 (1), pp.14-9. ⟨10.1086/595566⟩ Journal of Infectious Diseases, 2009, 199 (1), pp.14-9. ⟨10.1086/595566⟩ |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/595566 |
| Popis: | International audience; BACKGROUND: A causal association links high-risk human papillomavirus (HR-HPV) and cervical cancer, which is a major public health problem. The objective of the present study was to investigate the association between male circumcision (MC) and the prevalence of HR-HPV among young men. METHODS: We used data from a MC trial conducted in Orange Farm, South Africa, among men aged 18-24 years. Urethral swab samples were collected during a period of 262 consecutive days from participants in the intervention (circumcised) and control (uncircumcised) groups who were reporting for a scheduled follow-up visit. Swab samples were analyzed using polymerase chain reaction. HR-HPV prevalence rate ratios (PRRs) were assessed using univariate and multivariate log Poisson regression. RESULTS: In an intention-to-treat analysis, the prevalences of HR-HPV among the intervention and control groups were 14.8% (94/637) and 22.3% (140/627), respectively, with a PRR of 0.66 (0.51-0.86) (P = .002). Controlling for propensity score and confounders (ethnic group, age, education, sexual behavior [including condom use], marital status, and human immunodeficiency virus status) had no effect on the results. CONCLUSIONS: This is the first randomized controlled trial to show a reduction in the prevalence of urethral HR-HPV infection after MC. This finding explains why women with circumcised partners are at a lower risk of cervical cancer than other women. |
| Databáze: | OpenAIRE |
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