Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases

Autor: Daniel Clemente, Leticia Leon, Antía García Fernández, Lydia Abasolo, Juan Carlos Nieto, Pilar Galan del Rio, Jaime de Inocencio, Alina Boteanu, J. Bachiller-Corral, Clara Udaondo, Juan Carlos López Robledillo, Jaime Arroyo Palomo
Rok vydání: 2021
Předmět:
Male
Chronic inflammatory arthritis
Longitudinal study
Diseases of the musculoskeletal system
Comorbidity
Disease
Pediatrics
Multisystemic autoimmune disorders
Severity of Illness Index
Cohort Studies
Risk Factors
Lupus Erythematosus
Systemic
Immunology and Allergy
Outpatient clinic
Longitudinal Studies
Child
Hospitalization
Antirheumatic Agents
Carrier State
Cohort
Population study
Female
medicine.symptom
Research Article
medicine.medical_specialty
Adolescent
Heart Diseases
Referral
Autoinflammatory diseases
Intensive Care Units
Pediatric
Asymptomatic
RJ1-570
Rheumatology
Rheumatic Diseases
Internal medicine
Intensive care
medicine
Humans
Childhood-onset rheumatic diseases
Obesity
Renal Insufficiency
Chronic
Glucocorticoids
SARS-CoV-2
business.industry
Hereditary Autoinflammatory Diseases
COVID-19
Length of Stay
Arthritis
Juvenile
Asthma
Logistic Models
RC925-935
Spain
Multivariate Analysis
Pediatrics
Perinatology and Child Health
Observational study
business
Zdroj: Pediatric Rheumatology Online Journal
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-8 (2021)
ISSN: 1546-0096
Popis: Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods An observational longitudinal study was conducted during the first year of the SARS-CoV-2 pandemic (March 2020–March 2021). All pediatric patients attended at the rheumatology outpatient clinics of six tertiary referral hospitals in Madrid, Spain, with a diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic and clinical characteristics and treatment regimens. We ran a multivariable logistic regression model to assess associated factors for outcomes. Results The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients (38.96%) were asymptomatic, 41 (53.25%) had a mild-moderate COVID-19 and 6 patients (7.79%) required hospital admission. The median length of hospital admission was 5 (2–20) days, one patient required intensive care and there were no deaths. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was previous use of glucocorticoids (OR 3.51; p = 0.00). No statistically significant risk factors for symptomatic COVID-19 were found in the final model. Conclusion No differences in COVID-19 outcomes according to childhood-onset rheumatic disease types were found. Results suggest that associated comorbidities and treatment with glucocorticoids increase the risk of hospital admission.
Databáze: OpenAIRE
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