Screening of African medicinal plants for antimicrobial and enzyme inhibitory activity
| Autor: | Kusamba Zacharie Chifundera, Ronald Kaminsky, Anthony D. Wright, Gabriele M. König, Jeannette Ndaya Tshibangu |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cell Survival
Plasmodium falciparum Microbial Sensitivity Tests Pharmacognosy KB Cells Drug Discovery Animals Humans Enzyme Inhibitors Medicinal plants Antibacterial agent Pharmacology chemistry.chemical_classification Plants Medicinal biology Traditional medicine Plant Extracts Biological activity Mycobacterium tuberculosis Protein-Tyrosine Kinases Antimicrobial biology.organism_classification Virology HIV Reverse Transcriptase Enzyme chemistry Congo Enzyme inhibitor biology.protein |
| Zdroj: | Journal of ethnopharmacology. 80(1) |
| ISSN: | 0378-8741 |
| Popis: | Seven plant species, belonging to different families, were collected in the eastern part of the Republic of Congo (Kivu) based on ethnopharmacological information. Their dichloromethane and methanolic extracts were tested for biological activity. Five of the seven collected plants exhibited antiplasmodial activity with IC(50) values ranging from 1.1 to 9.8 microg/ml. The methanolic extract of Cissampelos mucronata was the most active one showing activity against chloroquine sensitive (D6) and chloroquine resistant (W2) Plasmodium falciparum strains with IC(50) values of 1.5 and 1.1 microg/ml, respectively. Additionally, this extract significantly inhibited the enzyme tyrosine kinase p56(lck) (TK). The dichloromethane extract of Amorphophallus bequaertii inhibited the growth of Mycobacterium tuberculosis with a MIC of 100 microg/ml and the methanolic extract of Rubus rigidus inhibited the activity of both enzymes HIV1-reverse transcriptase (HIV1-RT) and TK p56(lck). |
| Databáze: | OpenAIRE |
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