Effectiveness of Amygdalus mongolica oil in hyperlipidemic rats and underlying antioxidant processes
| Autor: | Shu-fang Niu, Jia Wang, Quan-li Liu, Song-li Shi, He Wang, Yun-shan Zhao, Zhan-Jun Yang, Hong-bing Zhou, Qian-nan Zheng |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Blood lipids Hyperlipidemias Toxicology Antioxidants Lipid peroxidation Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hyperlipidemia medicine Animals Plant Oils Food science Rats Wistar chemistry.chemical_classification Glutathione peroxidase Vitamin E Glutathione medicine.disease Malondialdehyde Lipids Rats Enzyme Activation 030104 developmental biology Gene Expression Regulation chemistry Biochemistry 030220 oncology & carcinogenesis Female lipids (amino acids peptides and proteins) Lipid Peroxidation Prunus Oxidoreductases |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 80:1193-1198 |
| ISSN: | 1087-2620 1528-7394 |
| DOI: | 10.1080/15287394.2017.1367124 |
| Popis: | The seeds of Amygdalus mongolica contain various constituents including flavonoids and vitamin E, which are known to exert antioxidant effects. However, the safety of the oil extract of this compound is not fully known. The aim of this study was to determine the physicochemical properties of A. mongolica oil, identify the constituents and subsequently assess the effectiveness of utilizing this seed extract in hyperlipidemia as an antioxidant agent. In particular, the toxicity and safety of A. mongolica oil were examined with emphasis on effects on blood lipids level and serum lipid peroxidation using a hyperlipidemia rat model. Treatment with 20 ml/kg A. mongolica oil produced no apparent adverse effects after 14 days in normal female and male rats. A dose of 2.5-10 ml/kg A. mongolica oil administered to hyperlipidemic male rats significantly decreased serum total cholesterol (TC), low-density lipoprotein-C (LDL-C), malondialdehyde (MDA), total cholesterol high-density lipoprotein-C (TC/HDL-C), LDL-C/HDL-C, and atherosclerosis index(AI). In contrast, glutathione (GSH) levels and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly increased. Data demonstrated that A. mongolica oil may be utilized in conditions of hyperlipidemia due to its antioxidant effects. |
| Databáze: | OpenAIRE |
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