Clinical Characteristics of Stenotrophomonas maltophilia Keratitis
| Autor: | Lung-Kun Yeh, An-Lun Wu, Hung-Chi Chen, David Hui-Kang Ma, Chi-Chin Sun, Hsin-Chiung Lin, Phil Y. F. Chen, Ching-Hsi Hsiao, Hsin-Yuan Tan, Shin-Yi Chen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Corneal Infection Visual acuity genetic structures Adolescent medicine.drug_class Stenotrophomonas maltophilia 030106 microbiology Antibiotics Visual Acuity Microbial Sensitivity Tests Eye Infections Bacterial Keratitis 03 medical and health sciences 0302 clinical medicine Risk Factors polycyclic compounds Medicine Humans Corneal Ulcer Aged Retrospective Studies Aged 80 and over biology business.industry Retrospective cohort study Eye infection Middle Aged bacterial infections and mycoses medicine.disease corneal ulcer biology.organism_classification Dermatology eye diseases Anti-Bacterial Agents Ophthalmology 030221 ophthalmology & optometry bacteria Female medicine.symptom business Gram-Negative Bacterial Infections Fluoroquinolones |
| Zdroj: | Cornea. 35(6) |
| ISSN: | 1536-4798 |
| Popis: | Stenotrophomonas maltophilia is an important opportunistic pathogen but an uncommon cause of corneal infections. This study aimed to report the clinical features, antibiotic susceptibility, treatments, and visual outcomes of S. maltophilia keratitis.The medical records of 21 patients with culture-proven S. maltophilia-associated infectious keratitis in our hospital between January 1, 2003, and December 31, 2014, were retrospectively reviewed. The clinical features of patients with S. maltophilia keratitis were compared with those of patients from 17 previously reported cases.The most common risk factors for S. maltophilia keratitis were preexisting corneal disease or previous corneal surgery (16), followed by soft contact lens wear (9). Nine patients (42.9%) were multifactorial. Polymicrobial infections was detected in 12 eyes (57.1%). All S. maltophilia isolates were susceptible to levofloxacin and moxifloxacin. A total of 17 of 21 patients (81.0%) had favorable responses to topical antimicrobial treatment, and 10 (47.6%) required surgical intervention for promotion of reepithelialization (6) and corneal perforation (4). Final vision ranged from light perception to 20/20. The clinical features of S. maltophilia keratitis in our cases and in previously reported cases were similar.S. maltophilia keratitis primarily affects patients with compromised ocular surfaces. S. maltophilia demonstrates in vitro susceptibility and a strong clinical response to fluoroquinolones. |
| Databáze: | OpenAIRE |
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