Effects of RU 52583, an alpha 2-antagonist, on memory in rats with excitotoxic damage to the septal area
| Autor: | A.-M Palou, C Oberlander, C. Bardelay, M M'Harzi, F Willig |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Physostigmine N-Methylaspartate medicine.drug_class Clinical Biochemistry Hippocampal formation Muscarinic Agonists Toxicology Biochemistry Spatial memory Hippocampus Choline Lesion Behavioral Neuroscience Idazoxan Memory Internal medicine medicine Excitatory Amino Acid Agonists Animals Theta Rhythm Maze Learning Vinca Alkaloids Biological Psychiatry Adrenergic alpha-Antagonists Pharmacology Chemistry Antagonist Adrenergic alpha-2 Receptor Antagonists Receptor antagonist Rats Endocrinology Anesthesia NMDA receptor Septal Nuclei Cholinesterase Inhibitors medicine.symptom medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 56(4) |
| ISSN: | 0091-3057 |
| Popis: | The anti-amnesic action of RU 52583, an alpha 2-adrenergic receptor antagonist, was evaluated through performance of spatial tasks in a radial maze by rats with N-methyl-D-aspartic acid (NMDA) lesion of the medial septal (MS) nuclei. Memory performance of lesioned or sham-operated rats was evaluated by measuring reference memory as long-term maintenance of an acquired performance and working memory or memory for recent events. The lesion: a produced significant impairments of the animals' memory performance, b) significantly reduced the sodium-dependent high-affinity choline uptake in the hippocampal formation, and c) deeply disrupted cholinergic hippocampal theta waves. Oral administration of RU 52583 at 1 and 2 mg/kg (tested doses: 1-5 mg/kg) prior to performance of the task markedly reduced memory impairments, whereas idazoxan, another alpha 2-adrenergic receptor antagonist, had no effect at tested doses (2-5 mg/kg). Cholinergic drugs--arecoline at 0.1 and 1 mg/kg (tested doses: 0.05-1 mg/kg) and physostigmine at 0.02 and 0.1 mg/kg (tested doses: 1, 2, and 5 mg/kg)-administered intraperitoneally showed a tendency to alleviate memory deficits. The present results show that the alpha 2-adrenergic antagonist RU 52583 possesses cognition-enhancing properties in rats with damage to the septohippocampal system. |
| Databáze: | OpenAIRE |
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