The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility in an Iranian cohort

Autor:	Behnam Alipoor, Mirdavood Omrani, Maryam Tabasinezhad, Reza Mirfakhraie, Hamid Ghaedi, Andrea Masotti, Fazlollah Shokri, Abolfazl Movafagh
Rok vydání:	2016
Předmět:	Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Single-nucleotide polymorphism Iran Polymerase Chain Reaction Polymorphism Single Nucleotide Gastroenterology Cohort Studies 03 medical and health sciences Endocrinology Risk Factors Polymorphism (computer science) Internal medicine Diabetes mellitus Genotype medicine Humans Genetic Predisposition to Disease education Base Pairing Genetics education.field_of_study Base Sequence business.industry Computational Biology Type 2 Diabetes Mellitus Middle Aged medicine.disease MicroRNAs 030104 developmental biology Blood pressure Diabetes Mellitus Type 2 Case-Control Studies Cohort Female business Biomarkers Polymorphism Restriction Fragment Length
Zdroj:	Europe PubMed Central
ISSN:	1720-8386
Popis:	The study was aimed at investigating the association between hsa-mir-27a polymorphism rs895819 (T/C) and type 2 diabetes mellitus (T2DM) susceptibility in a large Iranian cohort. In this case–control study, the investigated population consisted of T2DM patients (n = 204) and sex- and age-matched controls (n = 209). We used the polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) for genotyping. We observed significant differences between T2DM patients and controls for weight (p = 0.002), BMI (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e26f0c8b97249ba423151028231d1c https://doi.org/10.1007/s40618-016-0499-4 Zobrazit plný text záznamu Full text from SpringerLink