Ran signaling in melanoma: Implications for the development of alternative therapeutic strategies
| Autor: | Paolo A. Ascierto, Ena Wang, Ernesta Cavalcanti, Mariaelena Capone, Valeria De Giorgi, Anna Maria Anniciello, Nicola Mozzillo, Bartolomea Ficili, Emilia Caputo, Francesco M. Marincola, Salvatore Travali, Gerardo Botti, Anna Valentino, Annalisa Fico, Stefania Crispi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Ran signaling Pathway analysis Down-Regulation Biology Transfection Article Targeted therapy Cell Line Tumor medicine Humans PTEN Gene silencing Aurora kinase A in melanoma Gene expression Melanoma Gene knockdown Gene Expression Profiling AURKA Gene medicine.disease Gene expression profiling ran GTP-Binding Protein Oncology Ran biology.protein Cancer research Aurora Kinase A Signal Transduction |
| Zdroj: | Cancer letters 357 (2015): 286–296. doi:10.1016/j.canlet.2014.11.033 info:cnr-pdr/source/autori:Caputo E, Wang E, Valentino A, Crispi S, De Giorgi V, Fico A, Ficili B, Capone M, Anniciello A, Cavalcanti E, Botti G, Mozzillo N, Ascierto PA, Marincola FM, Travali S./titolo:Ran signaling in melanoma: Implications for the development of alternative therapeutic strategies./doi:10.1016%2Fj.canlet.2014.11.033/rivista:Cancer letters (Print)/anno:2015/pagina_da:286/pagina_a:296/intervallo_pagine:286–296/volume:357 |
| Popis: | We performed a comparative study between two human metastatic melanoma cell lines (A375 and 526), and melanocytes (FOM78) by gene expression profiling and pathway analysis, using Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) software. Genes involved in Ran signaling were significantly over-represented (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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