Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor
| Autor: | Azam Mansouri, Mehdi Nematbakhsh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Angiotensin receptor Mean arterial pressure Short Communication Mas receptor Angiotensin II receptors 030204 cardiovascular system & hematology angtensin1-7 angiotensin ii receptors mas receptor gender rat 03 medical and health sciences 0302 clinical medicine Angtensin1-7 Pharmacy and materia medica Internal medicine Renin–angiotensin system Medicine General Pharmacology Toxicology and Pharmaceutics Receptor business.industry Antagonist Gender RS1-441 medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Renal blood flow Vascular resistance Rat business |
| Zdroj: | Research in Pharmaceutical Sciences, Vol 13, Iss 2, Pp 177-180 (2018) Research in Pharmaceutical Sciences |
| ISSN: | 1735-9414 1735-5362 |
| Popis: | Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats. However, A779 compared to vehicle increased RBF (18% vs 3%) and decreased RVR (13% vs 4%) responses to Ang1-7 infusion significantly (P < 0.05) in male when AngII receptors were blocked. Such observation was not occurred in female animals. Finally it was concluded that renal vascular responses to Ang1-7 administration may not be exerted by MasR in male rats, and these responses are not mediated with AngII receptors. |
| Databáze: | OpenAIRE |
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