Ultrastructure of the Endolymphatic Sac in Two-phase Endolymphatic Hydrops in the Guinea Pig
| Autor: | J. Verheul, F. W. J. Albers, E. H. Blaauw, Hero P. Wit, J. M. Segenhout, Erwin A. Dunnebier |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
hydrops
Pathology medicine.medical_specialty Endolymph Guinea Pigs Dissection (medical) Biology Endolymphatic sac Guinea pig otorhinolaryngologic diseases medicine Animals Endolymphatic Hydrops Inner ear Endolymphatic hydrops Aldosterone Meniere Disease INNER-EAR General Medicine Anatomy Fluid transport medicine.disease ultrastructure MODEL Microscopy Electron medicine.anatomical_structure Otorhinolaryngology Chronic Disease Ultrastructure Female sense organs Endolymphatic Sac Sodium-Potassium-Exchanging ATPase guinea pig |
| Zdroj: | Acta oto-Laryngologica, 119(3), 345-350 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.1080/00016489950181378 |
| Popis: | Two-phase endolymphatic hydrops is a subtle experimental model for Meniere's disease. Chronic dysfunction of the endolymphatic sac, induced by dissection of the most distal part without causing damage to the intermediate part, is combined with increased endolymph production induced by administration of aldosterone which stimulates the Na/K-ATPase in the stria vascularis. A transmission electron microscopic study was performed on the endolymphatic sacs of four groups of guinea pig cochleas: controls; non-operated aldosterone-treated cochleas: operated (dissection of the endolymphatic sac) cochleas; operated and aldosterone-treated cochleas. Light and electron microscopy showed a normal morphology in the controls. Aldosterone treatment had no visible effect. Dissected ears revealed severe deviations. The epithelium of the intermediate sac was low, showed dilated lateral intercellular spaces indicating elevated fluid transport and displayed serious degenerative processes. Distally, the endolymphatic sac was completely blocked by newly formed bone. Additional aldosterone treatment had no cumulative effect on the dissected ears. |
| Databáze: | OpenAIRE |
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