Identification of novel phasiRNAs loci on long non-coding RNAs in Arabidopsis thaliana
| Autor: | Lan Yu, Yijun Meng, Zhihong Yang, Rongkai Guo, Chaogang Shao, Yeqin Jiang, Xinghuo Ye |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Small RNA Arabidopsis Computational biology 01 natural sciences Gossypium hirsutum 03 medical and health sciences chemistry.chemical_compound Gene Expression Regulation Plant Genetics Aromatic amino acids RNA Small Interfering 030304 developmental biology Regulation of gene expression Gossypium 0303 health sciences Oryza sativa biology Oryza biology.organism_classification Plant development chemistry Genetic Loci RNA Plant RNA Long Noncoding Soybeans 010606 plant biology & botany |
| Zdroj: | Genomics. 111:1668-1675 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2018.11.017 |
| Popis: | Long non-coding RNAs (lncRNAs) are the "dark matters"involved in gene regulation with complex mechanisms. However, the functions of most lncRNAs remain to be determined. Our previous work revealed a massive number of degradome-supported cleavage signatures on Arabidopsis lncRNAs. Some of them have been confirmed associated with miRNAs-like sRNAs production, while others without long stem structure remain unexplored. A systematical search for phasiRNAs generating ability of these lncRNAs was conducted. Eight novel small RNA triggered lncRNA-phasiRNA pathways were discovered and three of them were found to be conserved in Arabidopsis, Oryza sativa, Glycine max and Gossypium hirsutum. Besides, Five novel ta-siRNAs derived from these lncRNAs were further identified to be involved in the regulation of plant development, stress responses and aromatic amino acids synthesis. These results substantially expanded the gene regulation mechanisms of lncRNAs. |
| Databáze: | OpenAIRE |
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