Effects of partial sympathectomy of brown fat or of adrenomedullectomy on catecholamine metabolism in cold-reared rats
| Autor: | René Portet, R. Bertin, Françoise de Marco |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine medicine.medical_treatment Stimulation Biology Rats Sprague-Dawley Basal (phylogenetics) Norepinephrine Catecholamines Adipose Tissue Brown Internal medicine Brown adipose tissue Adrenal Glands medicine Animals Sympathectomy Denervation General Medicine Rats Endocrinology medicine.anatomical_structure Turnover Catecholamine medicine.drug |
| Zdroj: | Comparative biochemistry and physiology. Part A, Physiology. 114(3) |
| ISSN: | 1096-4940 |
| Popis: | 1) The aim of this work was to study the effects of surgical denervation of the interscapular brown adipose tissue (IBAT) and of bilateral adrenal demedullation on cold adaptation of rats. 2) After sympathectomy in the 28 degree C rats, there were substantial decreases in the IBAT NE basal level and turnover rate but no modifications in the heart and adrenals. In the 16 degree C rats there were also decreases in the basal level and turnover rate of the IBAT NE but, in addition, significant increases in levels and turnover rates of NE in the heart and of epinephrine in the adrenals. 3) Bilateral adrenal demedullation led to increases in the NE basal level and turnover rate in the IBAT and the heart in the 16 degree C rats; no effects were observed in the 28 degree C rats. 4) It is concluded that in rats born and reared in a mild cold environment a compensatory stimulation of catecholamine production and turnover rate occurs in some organs after a partial sympathectomy of BAT or bilateral adrenal demedullation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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