High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger
| Autor: | N. Nathan, T. Borel, Sibylle Gerstl, Suzanne Chanteau, Ali Djibo, M. Guillerm, Philippe J Guerin, Fati Sidikou, Angela M. C. Rose |
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| Přispěvatelé: | Epicentre [Paris] [Médecins Sans Frontières], Médecins sans Frontières, Médecins Sans Frontières, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Réseau International des Instituts Pasteur (RIIP), Ministère de la santé publique et de la lutte contre les endémies |
| Rok vydání: | 2005 |
| Předmět: |
Serotype
030231 tropical medicine Meningitis Meningococcal Neisseria meningitidis medicine.disease_cause Meningococcal disease Polymerase Chain Reaction Sensitivity and Specificity MESH: Neisseria meningitidis Microbiology 03 medical and health sciences 0302 clinical medicine Medicine Humans False Positive Reactions 030212 general & internal medicine Niger False Negative Reactions MESH: False Negative Reactions Rapid diagnostic test MESH: Humans biology MESH: False Positive Reactions business.industry MESH: Latex Fixation Tests Public Health Environmental and Occupational Health MESH: Meningitis Meningococcal MESH: Polymerase Chain Reaction General Medicine Gold standard (test) biology.organism_classification medicine.disease MESH: Niger MESH: Sensitivity and Specificity 3. Good health Latex fixation test Infectious Diseases [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Parasitology Neisseriaceae business Meningitis Latex Fixation Tests |
| Zdroj: | Transactions of The Royal Society of Tropical Medicine and Hygiene Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2006, 100 (10), pp.964-9. ⟨10.1016/j.trstmh.2006.03.002⟩ |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/j.trstmh.2006.03.002⟩ |
| Popis: | There is a great need for a rapid diagnostic test to guide vaccine choice during outbreaks of meningococcal meningitis in resource-poor countries. During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. Results from 484 samples showed a sensitivity of 88% (95% CI 85-91%) and a specificity of 93% (95% CI 90-95%). Pastorex could be a good alternative to current methods, as it can be performed in a local laboratory with rapid results and is highly specific. Sensitivity can be improved with prior microscopy where feasible. A study specifically to evaluate the Pastorex test under epidemic conditions, using laboratories with limited resources, is recommended. |
| Databáze: | OpenAIRE |
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