Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy
| Autor: | Olukemi Adetutu Osukoya, Abidemi Paul Kappo, Babatunji Emmanuel Oyinloye, Precious Eseose Agboinghale, Basiru Olaitan Ajiboye, Lisa Ilobekemen Ekakitie, Oluwafemi Adeleke Ojo |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Pharmacology medicine.disease_cause Diabetic nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Alloxan Internal Medicine medicine Glucose homeostasis Glutathione transferase activity chemistry.chemical_classification business.industry Glutathione peroxidase medicine.disease 030104 developmental biology chemistry 030220 oncology & carcinogenesis business Oxidative stress Research Article |
| Zdroj: | J Diabetes Metab Disord |
| Popis: | BACKGROUND: Gongronema latifolium leaf is used traditionally to treat diabetes and other diseases. The present study aimed to provide the modulatory effect of G. latifolium on hyperglycemia, inhibitory effect of redox imbalance and inflammation in alloxan-induced nephropathy in Wistar rats. METHODS: Alloxan monohydrate was used to induce diabetes by an intraperitoneal injection of (150 mg/kg). Three diabetic groups were administered aqueous leaf extract of G. latifolium at 6.36, 12.72 and 25.44 mg/kg bodyweight (BW) respectively; a group was administered with metformin (5 mg/kg BW), while the other two were served as positive and negative control. Thereafter, fasting blood glucose, antioxidant enzymes, malondialdehyde (MDA) level, interleukin 2 and 6 were determined. RESULTS: G. latifolium leaf significantly (p |
| Databáze: | OpenAIRE |
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