Regional Nodal Irradiation in Early-Stage Breast Cancer
| Autor: | Pierre Rousseau, Ivo A. Olivotto, Boon Chua, Julia White, Bingshu E. Chen, Kathleen I. Pritchard, Yvonne Murray, Judy Anne W. Chapman, Susan Chafe, Abdenour Nabid, André Fortin, Mark Levine, Peter S. Craighead, David R. McCready, J. Bowen, Timothy J. Whelan, Lee Manchul, Ida Ackerman, Maureen C. Nolan, Katherine A. Vallis, Lori J. Pierce, Karen A. Gelmon, Wendy R. Parulekar |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Axillary lymph nodes business.industry medicine.medical_treatment Cancer Breast Neoplasms General Medicine medicine.disease Article Surgery Radiation therapy Breast cancer medicine.anatomical_structure Lymphatic Metastasis medicine Humans Female Stage (cooking) skin and connective tissue diseases business Mastectomy Survival analysis |
| Popis: | BackgroundMost women with breast cancer who undergo breast-conserving surgery receive whole-breast irradiation. We examined whether the addition of regional nodal irradiation to whole-breast irradiation improved outcomes. MethodsWe randomly assigned women with node-positive or high-risk node-negative breast cancer who were treated with breast-conserving surgery and adjuvant systemic therapy to undergo either whole-breast irradiation plus regional nodal irradiation (including internal mammary, supraclavicular, and axillary lymph nodes) (nodal-irradiation group) or whole-breast irradiation alone (control group). The primary outcome was overall survival. Secondary outcomes were disease-free survival, isolated locoregional disease-free survival, and distant disease-free survival. ResultsBetween March 2000 and February 2007, a total of 1832 women were assigned to the nodal-irradiation group or the control group (916 women in each group). The median follow-up was 9.5 years. At the 10-year follow-up, there was n... |
| Databáze: | OpenAIRE |
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