Regional Transmission Pattern of HIV-1 Non-CRF01_AE Strains Circulating in Hebei Province, China
| Autor: | Yan Li, Cuiying Zhao, Ning An, Xinli Lu, Yingying Wang, Suliang Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine China Immunology Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause Men who have sex with men law.invention 03 medical and health sciences 0302 clinical medicine Beijing law Virology medicine Cluster Analysis Humans 030212 general & internal medicine Homosexuality Male Heterosexuality Phylogeny Likelihood Functions Genetic diversity Sexual exposure Phylogenetic tree Genetic Variation virus diseases Sequence Analysis DNA 030104 developmental biology Infectious Diseases Transmission (mechanics) Communicable Disease Control HIV-1 Demography |
| Zdroj: | AIDS Research and Human Retroviruses. 34:222-227 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2017.0166 |
| Popis: | HIV-1 genetic diversity has recently been more and more complicated in Hebei province. To know about the transmission pattern of HIV-1 in Hebei, the phylogenetic analysis of non-CRF01_AE strains was performed using the maximum-likelihood (ML) method. Four clusters and two clusters were observed in the CRF07_BC and subtype B ML tree, respectively. Of these clusters, men who have sex with men (MSM) sequences were the most frequent, and no pure heterosexual cluster was found in this study. Our findings highlighted the close transmission relationship between the main HIV-1 non-CRF01_AE strains and the sexual exposure especially among MSM between neighboring provinces, such as Beijing and Liaoning, and Hebei. This provides new evidence that the main strains of HIV-1 were introduced into Hebei through sexual exposure especially among MSM from neighboring provinces, suggesting that it is urgent for us to take measures together with neighboring provinces to cut off HIV-1 dissemination chain through MSM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|