Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat
| Autor: | Jaroslav Vorlíček, Alena Musilova, Zídek, M Pravenec, Theodore W. Kurtz, St Lezin E, Kren |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Genotype Physiology Diastole Congenic Blood Pressure Quantitative trait locus Biology Rats Inbred WKY Chromosomes Spontaneously hypertensive rat Quantitative Trait Heritable Animals Congenic Internal medicine Rats Inbred BN Rats Inbred SHR Internal Medicine medicine Animals cardiovascular diseases Gene Genetics Strain (biology) Myocardium Hemodynamics Chromosome Chromosome Mapping Rats Blood pressure Endocrinology Hypertension cardiovascular system Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of hypertension. 19(6) |
| ISSN: | 0263-6352 |
| Popis: | Objectives Total genome scans of genetically segregating populations derived from the spontaneously hypertensive rat (SHR) and other rat models of hypertension have suggested the presence of quantitative trait loci (QTL) regulating blood pressure and cardiac mass on multiple chromosomes, including chromosome 2. The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2. Design A new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the corresponding chromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry. Results We found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy. Conclusions These findings demonstrate that gene(s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR.BN congenic strain. |
| Databáze: | OpenAIRE |
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