Magnetic Manganese Oxide Sweetgum-Ball Nanospheres with Large Mesopores Regulate Tumor Microenvironments for Enhanced Tumor Nanotheranostics
| Autor: | Dandan Ding, Wenjing Sun, Tianhang Shi, Li Luo, Hongmin Chen, Xiaoyuan Chen, Shanshan Meng, Yuwei Qiu, Yushuo Feng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Porphyrins medicine.medical_treatment chemistry.chemical_element Nanotechnology Photodynamic therapy 02 engineering and technology Manganese 010402 general chemistry 01 natural sciences chemistry.chemical_compound Mice In vivo Cell Line Tumor medicine Tumor Microenvironment Animals Humans General Materials Science Doxorubicin Magnetite Nanoparticles Tumor microenvironment Mice Inbred BALB C Chlorophyllides Oxides Neoplasms Experimental 021001 nanoscience & nanotechnology 0104 chemical sciences Nanomedicine chemistry Manganese Compounds Female 0210 nano-technology Mesoporous material human activities Porosity Iron oxide nanoparticles Nanospheres medicine.drug |
| Zdroj: | ACS applied materialsinterfaces. 11(41) |
| ISSN: | 1944-8252 |
| Popis: | An important objective of cancer nanomedicine is to improve the delivery efficacy of functional agents to solid tumors for effective cancer imaging and therapy. Stimulus-responsive nanoplatforms can target and regulate the tumor microenvironment (TME) for the optimization of cancer theranostics. Here, we developed magnetic manganese oxide sweetgum-ball nanospheres (MMOSs) with large mesopores as tools for improved cancer theranostics. MMOSs contain magnetic iron oxide nanoparticles and mesoporous manganese oxide (MnO2) nanosheets, which are assembled into gumball-like structures on magnetic iron oxides. The large mesopores of MMOSs are suited for cargo loading with chlorin e6 (Ce6) and doxorubicin (DOX), thus producing so-called CD@MMOSs. The core of magnetic iron oxides could achieve magnetic targeting of tumors under a magnetic field (0.25 mT), and the targeted CD@MMOSs may decompose under TME conditions, thereby releasing loaded cargo molecules and reacting with endogenous hydrogen peroxide (H2O2) to generate oxygen (O2) and manganese (II) ions (Mn2+). Investigation in vivo in tumor-bearing mice models showed that the CD@MMOS nanoplatforms achieved TME-responsive cargo release, which might be applied in chemotherapy and photodynamic therapy. A remarkable in vivo synergy of diagnostic and therapeutic functionalities was achieved by the decomposition of CD@MMOSs and coadministration with chemo-photodynamic therapy of tumors using the magnetic targeting mechanism. Thus, the result of this study demonstrates the feasibility of smart nanotheranostics to achieve tumor-specific enhanced combination therapy. |
| Databáze: | OpenAIRE |
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