Studies on the mechanism of polyclonal B cell stimulation by TH2 cells
| Autor: | Peter Rohwer, Meike Dirks, Martin Röllinghoff, Michael Lohoff |
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| Rok vydání: | 1989 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte CD3 Complex Lymphocyte Cooperation Immunology B-cell receptor Antigen presentation Naive B cell Receptors Antigen T-Cell Mice Nude Antigens Protozoan Lymphocyte Activation Mice Interleukin 21 medicine Animals Immunology and Allergy Cytotoxic T cell Antigen-presenting cell B cell B-Lymphocytes Mice Inbred BALB C CD40 Cell-Free System biology Macrophages Antibodies Monoclonal T-Lymphocytes Helper-Inducer Virology Clone Cells Immunoglobulin Fc Fragments Cell biology medicine.anatomical_structure Leishmania tropica biology.protein Female |
| Zdroj: | European Journal of Immunology. 19:77-81 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830190113 |
| Popis: | Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2 -cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during stimulation of the B cells by activated T cells, can be mediated by a mechanism other than cognate interaction. This conclusion is derived from experiments in which highly purified, small B cells of high density were polyclonally stimulated by L1/1 T cells triggered by an anti-T3 monoclonal antibody in the absence of antigen. The triggering process was independent of the presence of the Fc part of the antibody and occurred in cultures devoid of macrophages. Thus, the well-established cognate recognition does not appear to be the only mechanism of B cell induction by T helper cells. |
| Databáze: | OpenAIRE |
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