Bioaccumulation of CuO nanomaterials in rainbow trout: Influence of exposure route and particle shape
| Autor: | Judit Kalman, Mona Connolly, Fazel Abdolahpur-Monikh, Rocío Fernández-Saavedra, Ana I. Cardona-García, Estefanía Conde-Vilda, Salome Martínez-Morcillo, Willie J.G.M. Peijnenburg, Isabel Rucandio, María Luisa Fernández-Cruz |
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| Přispěvatelé: | European Commission, Comunidad de Madrid, Kalman, Judit, Connolly, Mona, Abdolahpur-Monikh, Fazel, Fernández-Saavedra, Rocío, Peijnenburg, Willie J G M, Rucandio, Isabel, Fernández-Cruz, María Luisa |
| Rok vydání: | 2022 |
| Předmět: |
Environmental Engineering
Exposure route Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Water General Medicine General Chemistry Nanoform Protect restore and promote sustainable use of terrestrial ecosystems sustainably manage forests combat desertification and halt and reverse land degradation and halt biodiversity loss Pollution Bioaccumulation Bioconcentration Nanostructures Fish Oncorhynchus mykiss Environmental Chemistry Animals Tissue Distribution Single-particle ICP MS Water Pollutants Chemical Copper Biomagnification |
| Zdroj: | Chemosphere, 310:136894 Chemosphere |
| ISSN: | 1879-1298 |
| Popis: | Departamento de Medio Ambiente y Agronomía The bioaccumulation potential of spherical and rod-shaped CuO nanomaterials (NMs) was assessed in rainbow trout (Oncorhynchus mykiss) exposed via water and diet following the OECD Test Guideline No. 305. Fish were exposed via diet to both NMs at concentrations of 70 and 500 mg Cu/kg for 15 days, followed by 44 days of depuration. For water-borne exposure, only the rod-shaped CuO NMs were tested at 0.08 and 0.8 mg Cu/L for 28 days, followed by 14 days of depuration. The concentration of Cu was determined in fish whole body to derive biomagnification and bioconcentration factors (BMF and BCF). Different tissues were sampled to investigate the total Cu biodistribution and target organs as well as the particle number-based bioaccumulation of CuO NMs. Estimated BMF and BCF values were below the thresholds of concern. However, shape and route influenced depuration. Following dietary exposure, there was a higher depuration of Cu from fish exposed to the rod-shaped compared to the spherical CuO NMs. A higher depuration was also observed for rod-shaped CuO NMs following the dietary exposure compared the aqueous one. Despite the much higher dietary exposure concentrations of rod-shape CuO NMs, similar Cu body burdens were reached via water. Cu was found in particulate form in different tissues. Although these NMs had a low bioaccumulation potential, differences in distribution and elimination patterns of Cu were observed depending on the exposure route and particle shape. Careful consideration of the most relevant exposure route is needed when designing a bioaccumulation experiment for testing NMs. This work was funded through the H2020 project Gov4Nano (Grant Agreement nº 814401). Authors thank all the effort done at the National Centre for Electron Microscopy (Spain) in relation to the electron microscopy work. Mona Connolly has received financing granted by the Community of Madrid (2018T2/AMB-11392, Mode 2, Young Doctor Recruitment). |
| Databáze: | OpenAIRE |
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