Aerobic Training and Circulating Neurotrophins in Alzheimer’s Disease Patients: A Controlled Trial

Autor: Angelica Miki Stein, Flávia Gomes de Melo Coelho, Thays Martins Vital-Silva, André Veloso Rueda, Jessica Rodrigues Pereira, Andréa Camaz Deslandes, Rosana Camarini, Ruth Ferreira Santos Galduróz
Přispěvatelé: UTFPR: Universidade Tecnológica Federal do Paraná, Universidade Federal do Triangulo Mineiro, Instituto Federal do Triângulo Mineiro, Universidade de São Paulo (USP), Universidade Estadual Paulista (UNESP), Universidade Federal do Rio de Janeiro (UFRJ), Universidade Federal do ABC (UFABC)
Rok vydání: 2022
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1096-4657
0361-073X
Popis: Made available in DSpace on 2022-04-28T19:51:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Objective: to verify the effects of aerobic exercise training in circulating BDNF, VEGF165 and IGF-1 plasma levels and cognitive function in Alzheimer’s Disease (AD) patients. Methods: 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18–Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. Results: After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Conclusion: Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients. The Human Performance Research Group UTFPR: Universidade Tecnológica Federal do Paraná, PR Postgraduate Program in Physical Education UFTM Universidade Federal do Triangulo Mineiro Instituto Federal do Triângulo Mineiro, MG Department of Pharmacology Biomedical Sciences Institute USP: Universidade de Sao Paulo Institute of Biosciences UNESP: Universidade Estadual Paulista Julio de Mesquita Filho, SP Institute of Psychiatry UFRJ Universidade Federal do Rio de Janeiro, RJ Center of Mathematics Computing and Cognition UFABC Universidade Federal do ABC, SP Ufabc: Universidade Federal Do Abc Institute of Biosciences UNESP: Universidade Estadual Paulista Julio de Mesquita Filho, SP
Databáze: OpenAIRE
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