Prognostic value of sentinel lymph node biopsy according to Breslow thickness for cutaneous melanoma
| Autor: | Brian R. Gastman, Pauline Funchain, Evan Stiegel, David D. Xiong, Raymond Isakov, Jason Ya, Alok Vij |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Skin Neoplasms Multivariate analysis Sentinel lymph node Dermatology Disease-Free Survival Cohort Studies Breslow Thickness 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Humans Neoplasm Invasiveness Melanoma Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Proportional hazards model Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Rate Lymphatic Metastasis 030220 oncology & carcinogenesis Cutaneous melanoma Female Lymph Nodes business |
| Zdroj: | Journal of the American Academy of Dermatology. 78:942-948 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2018.01.030 |
| Popis: | Background Sentinel lymph node (SLN) biopsy is widely performed for melanoma with certain histologic parameters and offers important prognostic and staging information. Breslow thickness (BT) by itself also provides meaningful prognostic information. Objective To evaluate whether SLN status provides prognostic information independent from that which is already provided by BT. Methods We conducted a retrospective cohort study of 896 patients who underwent SLN biopsy for primary cutaneous melanoma. Stratified analysis of the impact of SLN status within BT groups (0.01-1 mm, 1.01-2.00 mm, 2.01-4.00 mm, and >4.00 mm) was performed. In addition, a Cox proportional hazard model was fit to evaluate the interaction between BT unadjusted and then adjusted for SLN status to determine whether predictive ability is improved. Results Having a negative SLN did not confer a statistically significant survival advantage for any BT subgroup ( P = .54, .075, .17, and .95 for subgroups 0.01-1 mm, 1.01-2.00 mm, 2.01-4.00 mm, and >4.00 mm, respectively). In multivariate analysis, SLN status did not demonstrate independent prognostic ability over that of BT alone ( P = .067). Limitations Retrospective study, single institution. Conclusion Our data suggest that SLN status does not offer better prognostic information for patients than BT alone. |
| Databáze: | OpenAIRE |
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