The prognostic value of histopathological pattern of the pelviureteric junction in the outcome of pyeloplasty in children
| Autor: | Tagreed Abdelsamee, Mohamed Abdelrahman, Ali Elshazli, Ahmed Sebaey, Tarek Gharib, Hammouda Sherif |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Surgical results
medicine.medical_specialty Pyeloplasty Urology medicine.medical_treatment 030232 urology & nephrology Pelviureteric junction obstruction Histopathology Pelviureteric junction lcsh:RC870-923 03 medical and health sciences 0302 clinical medicine Smooth muscle 030225 pediatrics medicine biology business.industry PUJO Significant difference lcsh:Diseases of the genitourinary system. Urology medicine.anatomical_structure biology.protein Radiology business Elastin Renal pelvis |
| Zdroj: | African Journal of Urology, Vol 26, Iss 1, Pp 1-6 (2020) |
| ISSN: | 1961-9987 1110-5704 |
| DOI: | 10.1186/s12301-020-00050-9 |
| Popis: | Background The cause of pyeloplasty failure remains unclear; therefore, increasing interest has been directed to identify the reason for dissatisfactory surgical results. Some studies attempted to investigate the role of the histopathological pattern. The aim of the work is to study the correlation between the histopathological pattern of obstructed pelviureteric junction (PUJ) segment and the outcome of pyeloplasty in children with the PUJ. Methods Fifty-four patients with pelviureteric junction obstruction (PUJO) were included in the study; patients were evaluated preoperative. All patients were operated by the same surgeon using Anderson–Hynes pyeloplasty; the resected obstructed PUJ segment examined histopathological using light microscope and image analyzer system to identify mean renal pelvis smooth muscle thickness (mRPSMT), collagen-to-smooth muscle ratio and elastin content. Results The study includes 50 patients with mean age Mean 24.48 ± 15.3 months. Two patients show no improvement, while 24 improved at 3 months, 16 improved at 6 months, and 8 improved at 12 months. mRPSMT showed significant difference between improvement groups (136.02 ± 44.4, 173.47 ± 49.69 and 258.56 ± 96.82 μm), while elastin content or collagen-to-smooth muscle ratio showed no significant difference. Conclusions Our data showed a clear relationship between mRPSMT and the time over which radiological improvement occurs; increase in mRPSMT is associated with a delay in postoperative radiological improvement time. We found no relation between elastin content nor collagen-to-smooth muscle thickness and postoperative improvement course. |
| Databáze: | OpenAIRE |
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