Metastatic Adrenocortical Carcinoma Co-Secreting Multiple Steroid Hormones
| Autor: | Robert Galagan, Tien-Hao Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Aldosterone business.industry Endocrinology Diabetes and Metabolism Urology Hyperplasia medicine.disease Plasma renin activity Hypokalemia chemistry.chemical_compound chemistry medicine Adrenocortical carcinoma Mitotane Adrenal - Clinical Research Studies medicine.symptom Adrenal business Testosterone AcademicSubjects/MED00250 medicine.drug Hormone |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| Popis: | Background: Adrenocortical carcinoma is a rare disease which may be complicated by co-secretion of multiple steroid hormones. Clinical Case: A 53- year-old female was discovered to have 1 cm left and 1.7 cm right adrenal nodules by Chest CT scan in 2004. She had a follow-up abdominal CT scan in 2011 revealing enlargement of the left adrenal mass to 5.7 cm and a stable 1.8 cm right adrenal nodule. A laparoscopic left adrenalectomy was performed in 2012 and the surgical pathology diagnosis was benign adrenal hyperplasia. In 5/2016 the patient developed left abdominal pain and a CT scan revealed a 1.7 cm mass in the left adrenalectomy surgical bed, a 1.4 cm nodular density adjacent to the left diaphragm and the stable 1.8 cm right adrenal nodule. 6/2016 lab tests: 24 hr urinary cortisol 15 ug/24 hr ( Conclusion: This case report details the rare occurrence of an adrenocortical carcinoma which was hormonally silent but eventually metastasized and became hormonally active, co-secreting multiple steroid hormones with a predominance of aldosterone. Serial adrenal hormone lab profiles are important for optimal management of patients with this disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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