Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar

Autor: Nastasia Pop, Ştefania Silvia Balea, Alina Elena Pârvu, Fernando Zamora Marin, Marcel Pârvu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Aging
Antioxidant
DPPH
medicine.medical_treatment
Myocardial Ischemia
Biochemistry
Antioxidants
Anthocyanins
chemistry.chemical_compound
Malondialdehyde
Stilbenes
Vitis
Food science
Chromatography
High Pressure Liquid
biology
lcsh:Cytology
food and beverages
04 agricultural and veterinary sciences
General Medicine
Free radical scavenger
040401 food science
Proanthocyanidin
Research Article
Spectrometry
Mass
Electrospray Ionization
Cardiotonic Agents
Article Subject
Aspartate transaminase
03 medical and health sciences
0404 agricultural biotechnology
medicine
Animals
Proanthocyanidins
lcsh:QH573-671
Rats
Wistar
Flavonoids
Nitrates
Plant Extracts
Pomace
Isoproterenol
Polyphenols
Cell Biology
Rats
Oxidative Stress
030104 developmental biology
chemistry
Polyphenol
biology.protein
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
ISSN: 1942-0994
1942-0900
Popis: Grape pomace is a potential source of natural antioxidant agents. Phenolic compounds and antioxidant and cardioprotective properties of fresh and fermented pomace extracts obtained from Vitis vinifera L. red variety Fetească neagră grown in Romania in 2015 were investigated. Grape pomace extracts total phenolic index, total tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes, and DPPH free radical scavenger were measured. The effect of a seven-day pretreatment with grape pomace extracts on the isoprenaline-induced infarct-like lesion in rats was assessed by ECG monitoring, serum levels of creatine kinase, aspartate transaminase, and alanine transaminase. Total serum oxidative status, total antioxidant response, oxidative stress index, malondialdehyde, total thiols, and nitric oxide have been also assessed. Higher phenolic content and antioxidant activity were found in fermented pomace extracts when compared to fresh pomace extracts. Pretreatment with grape pomace extracts significantly improved cardiac and oxidative stress parameters. In conclusion, Fetească neagră pomace extracts had a good in vitro antioxidant activity due to an important phenolic content. In vivo, the extracts had cardioprotective effects against isoprenaline-induced infarct-like lesion by reducing oxidative stress, fresh pomace extracts having a better effect.
Databáze: OpenAIRE
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