Plasma deoxyadenosine, adenosine, and erythrocyte deoxyATP are elevated at birth in an adenosine deaminase-deficient child
| Autor: | Rochelle Hirschhorn, Arye Rubinstein, Photini S Papageorgiou, Vivian Roegner |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Erythrocytes Adenosine Deaminase Nucleoside Deaminases Biology chemistry.chemical_compound Immune system Adenosine deaminase Deoxyadenine Nucleotides Deoxyadenosine Pregnancy Internal medicine Packed erythrocytes medicine Humans Maternal-Fetal Exchange Maternal-fetal exchange Deoxyadenosines Infant Newborn Infant General Medicine Fetal Blood Endocrinology chemistry Cord blood biology.protein Female medicine.drug Research Article |
| Zdroj: | The Journal of clinical investigation. 65(3) |
| ISSN: | 0021-9738 |
| Popis: | We have determined concentrations of adenosine, deoxyadenosine, and deoxyATP (dATP) in cord blood from an infant prenatally diagnosed as ADA deficient. Plasma deoxyadenosine and adenosine were already elevated in cord blood (0.7 and 0.5 microM vs. normal of less than 0.07 microM). Elevation of plasma deoxyadenosine has not previously been documented in these children. Erythrocyte dATP content was also elevated at birth (215 nmol/ml packed erythrocytes vs. normal of 2.9). These elevated concentrations of adenosine, deoxyadenosine, and dATP are similar to those we observed in another older adenosine deaminase-deficient patient and may explain the impaired immune function and lymphopenia seen at birth. |
| Databáze: | OpenAIRE |
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