Carbohydrate-basedClostridium difficilevaccines
| Autor: | Luis G. Arroyo, Michael Mallozzi, Zuchao Ma, Douglas C. Hodgins, Lisa Bertolo, John Sundsmo, Yuening Jiao, Martin Sagermann, Mario A. Monteiro, Herbert Chow, Gayatri Vedantam |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Glycan
Immunology macromolecular substances Epitope Microbiology Mice Antigen Cricetinae Drug Discovery Animals Humans Pharmacology Vaccines Conjugate biology Clostridioides difficile Immunogenicity Polysaccharides Bacterial food and beverages Carbohydrate Clostridium difficile Antibodies Bacterial Virology Immunoglobulin A Disease Models Animal Animals Domestic Immunoglobulin G Bacterial Vaccines biology.protein Molecular Medicine Antibody Antibiotic-associated diarrhea |
| Zdroj: | Expert Review of Vaccines. 12:421-431 |
| ISSN: | 1744-8395 1476-0584 |
| Popis: | Clostridium difficile is responsible for thousands of deaths each year and a vaccine would be welcomed, especially one that would disrupt bacterial maintenance, colonization and persistence in carriers and convalescent patients. Structural explorations at the University of Guelph (ON, Canada) discovered that C. difficile may express three phosphorylated polysaccharides, named PSI, PSII and PSIII; this review captures our recent efforts to create vaccines based on these glycans, especially PSII, the common antigen that has precipitated immediate attention. The authors describe the design and immunogenicity of vaccines composed of raw polysaccharides and conjugates thereof. So far, it has been observed that anti-PSII antibodies can be raised in farm animals, mice and hamster models; humans and horses carry anti-PSII IgA and IgG antibodies from natural exposure to C. difficile, respectively; phosphate is an indispensable immunogenic epitope and vaccine-induced PSII antibodies recognize PSII on C. difficile outer surface. |
| Databáze: | OpenAIRE |
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