Bilateral breast relapse in acute myelogenous leukemia
| Autor: | David A. Steele, Alice K. King, Stanley H. Konefal, Philip M. Monteleone, John F. Kelleher |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Oncology
medicine.medical_specialty Transplantation Conditioning Both breasts medicine.medical_treatment Biopsy Mammary gland Graft vs Host Disease Dexamethasone Radiotherapy High-Energy Myelogenous Leukemic Infiltration Recurrence hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Breast examination Humans Immunologic Factors Breast Child Thioguanine Bone Marrow Transplantation Etoposide Salvage Therapy Chemotherapy business.industry Daunorubicin Cytarabine medicine.disease Combined Modality Therapy Pathophysiology Surgery Radiation therapy Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Interleukin-2 Female business Idarubicin Vidarabine |
| Zdroj: | Journal of pediatric hematology/oncology. 23(2) |
| ISSN: | 1077-4114 |
| Popis: | We present the case of an 11.5-year-old girl with Ml acute myelogenous leukemia (AML) who had isolated extramedullary relapse develop in both breasts 12 months after diagnosis and 7 months off chemotherapy. She received further chemotherapy, focal radiation therapy, then underwent a matched, unrelated bone marrow transplant arid continues in remission 37 months later. Review of the literature revealed 10 cases in other children younger than 21-years-old with AML and breast involvement. These cases are summarized, and potential pathophysiologic mechanisms of spread are discussed. Breast involvement in AML is rare in children. However, regular breast examinations should be performed as part of routine follow-up in all girls with AML. |
| Databáze: | OpenAIRE |
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