Reduction in camera-specific variability in [123I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Autor: Andreas Kluge, Hidehiro Iida, L. Özlem Kapucu, Claus Svarer, Livia Tossici-Bolt, Osama Sabri, Andrea Varrone, Koen Van Laere, Marco Pagani, Terez Sera, Catharina Lange, Flavio Nobili, Ralph Buchert, Susanne Asenbaum, John Dickson, Thierry Vander Borght, Jan Booij, Klaus Tatsch, Pierre-Malick Koulibaly, Marcus Bronzel
Přispěvatelé: ANS - Brain Imaging, Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Databases
Factual
ENC-DAT
Iterative reconstruction
Binding ratio
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Reduction (complexity)
03 medical and health sciences
0302 clinical medicine
Age
Dopamine transporter scintigraphy
QSPECT
Specific binding ratio
[123I]FP-CIT
Radiology
Nuclear Medicine and Imaging
Nuclear Medicine and Imaging
Image Processing
Computer-Assisted
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Dopamine transporter
Tomography
Emission-Computed
Single-Photon
Dopamine Plasma Membrane Transport Proteins
biology
business.industry
Age Factors
Outcome measures
Array
Reconstruction algorithm
General Medicine
Clinical routine
Healthy Volunteers
Europe
biology.protein
Fp cit spect
Radiology
business
Nuclear medicine
030217 neurology & neurosurgery
Tropanes
Zdroj: European journal of nuclear medicine and molecular imaging (Internet) (2016): 1–14. doi:10.1007/s00259-016-3309-5
info:cnr-pdr/source/autori:Buchert R.; Kluge A.; Tossici-Bolt L.; Dickson J.; Bronzel M.; Lange C.; Asenbaum S.; Booij J.; Atay Kapucu L.O.; Svarer C.; Koulibaly P.-M.; Nobili F.; Pagani M.; Sabri O.; Sera T.; Tatsch K.; Vander Borght T.; van Laere K.; Varrone A.; Iida H./titolo:Reduction in camera-specific variability in [123I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls/doi:10.1007%2Fs00259-016-3309-5/rivista:European journal of nuclear medicine and molecular imaging (Internet)/anno:2016/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume
European journal of nuclear medicine and molecular imaging, 43(7), 1323-1336. Springer Verlag
Europe PubMed Central
ISSN: 1619-7070
DOI: 10.1007/s00259-016-3309-5
Popis: Purpose Quantitative estimates of dopamine transporter availability, determined with [123I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [123I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis. Methods Of 73 healthy subjects from the European Normal Control Database of [123I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEMreconstruction including attenuation correction, and camera-specific Bto kBq/ml^ calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [123I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure. Results The fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm. Conclusion QSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [123I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding.
Databáze: OpenAIRE
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