A genome-wide search for genes involed in type 2 diabetes in a recently genetically isolated population from the Netherlands
| Autor: | Peter Heutink, Ben A. Oostra, Lodewijk A. Sandkuijl, Norbert Vaessen, Mark Edwards, P.J.L.M. Snijders, Jeanine J. Houwing-Duistermaat, Jan Pullen, Yurii S. Aulchenko, Simon T. Bennett, Cornelia M. van Duijn, Albert Hofman |
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| Přispěvatelé: | Epidemiology, Clinical Genetics |
| Rok vydání: | 2003 |
| Předmět: |
Genetic Markers
Endocrinology Diabetes and Metabolism Locus (genetics) Type 2 diabetes Biology Body Mass Index SDG 3 - Good Health and Well-being Diabetes mellitus Internal Medicine medicine Humans Genetic Predisposition to Disease Genetic Testing Allele Gene Alleles Demography Genes Dominant Netherlands Genetics Genome Human Chromosome Mapping Odds ratio Middle Aged medicine.disease Founder Effect Diabetes Mellitus Type 2 Genetic marker Lod Score Chromosomes Human Pair 18 Founder effect |
| Zdroj: | Diabetes, 52(12), 3001-3004. American Diabetes Association Inc. |
| ISSN: | 0012-1797 |
| Popis: | Multiple genes, interacting with the environment, contribute to the susceptibility to type 2 diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes in a recently genetically isolated population in the Netherlands. We identified 79 nuclear families with type 2 diabetes who were related within 13 generations and performed a 770-marker genome-wide scan search for shared founder alleles. Twenty-six markers yielded a logarithm of odds (LOD) score >0.59 (nominal P < 0.05), of which 7 reached LOD scores >1.17 (nominal P < 0.01). The strongest evidence for a type 2 diabetes locus was at marker D18S63 on chromosome 18p (LOD 2.3, P = 0.0006). This region was investigated further using additional markers. For one of these markers (D18S1105), we found a significant association with type 2 diabetes (odds ratio 6.7 [95% CI 1.5–30.7], P = 0.005 for the 97-bp allele, assuming a dominant model), which increased when limiting the analysis to patients with high BMI (12.25 [2.1–71], P = 0.003). A locus on chromosome 18p in patients with high BMI was suggested earlier by Parker et al. Our study is the first to confirm this locus. |
| Databáze: | OpenAIRE |
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