New Oxoprotoberberine and Aporphine Alkaloids from the Roots of Amoora cucullata with Their Antiproliferative Activites
| Autor: | Passakorn Teerapongpisan, Jaraslak Pechwang, Parinuch Chumkaew, Theera Srisawat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
antiproliferative activity biology Traditional medicine Chemistry Organic Chemistry amoora cucullata Plant Science biology.organism_classification lcsh:QK1-989 lcsh:Chemistry lcsh:QD241-441 aporphine lcsh:QD1-999 lcsh:Organic chemistry Amoora lcsh:Botany Drug Discovery Aporphine alkaloids oxoprotoberberine |
| Zdroj: | Records of Natural Products, Vol 13, Iss 6, Pp 491-498 (2019) |
| ISSN: | 1307-6167 |
| Popis: | Two new oxoprotoberberine alkaloids, amocurine A and B (1 and 2), a new aporphine alkaloid, amocurine C (3), along with three known compounds (4-6) were isolated from the roots of Amoora cucullata. Their structures were determined by analysis of spectroscopic data. The isolated compounds were evaluated for their antiproliferative activity against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer). Compounds 3 showed the most potent activities against KB and MCF-7 cell lines with IC50 values 3.5 and 4.2 mM, respectively. |
| Databáze: | OpenAIRE |
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