Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients
| Autor: | M. Hernandez, M. Hecker, J. Pouso, G. Clavier, S. Fazio, D. Dolinsky, A. Fernandez |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Pharmaceutical Science Bronchi Young Adult Internal medicine Drug Discovery Concomitant Therapy medicine Humans Prospective Studies Prospective cohort study Adverse effect Bronchitis Child Aged Pharmacology Aged 80 and over business.industry Hedera Plant Extracts Incidence (epidemiology) Infant Middle Aged medicine.disease Surgery Clinical trial Plant Leaves Treatment Outcome Complementary and alternative medicine Concomitant Relative risk Child Preschool Molecular Medicine Female business Phytotherapy |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 16(1) |
| ISSN: | 1618-095X |
| Popis: | In this postmarketing study 9657 patients (5181 children) with bronchitis (acute or chronic bronchial inflammatory disease) were treated with a syrup containing dried ivy leaf extract. After 7 days of therapy, 95% of the patients showed improvement or healing of their symptoms. The safety of the therapy was very good with an overall incidence of adverse events of 2.1% (mainly gastrointestinal disorders with 1.5%). In those patients who got concomitant medication as well, it could be shown that the additional application of antibiotics had no benefit respective to efficacy but did increase the relative risk for the occurrence of side effects by 26%. In conclusion, it is to say that the dried ivy leaf extract is effective and well tolerated in patients with bronchitis. In view of the large population considered, future analyses should approach specific issues concerning therapy by age group, concomitant therapy and baseline conditions. |
| Databáze: | OpenAIRE |
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