Venlafaxine in Treatment-Resistant Obsessive-Compulsive Disorder
| Autor: | Lorrin M. Koran, Jennifer Friedberg, Eric Hollander, Stacey Wasserman, Andrea Allen, Melissa Birnbaum |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder medicine.medical_specialty Adolescent Venlafaxine Hydrochloride Pilot Projects Venlafaxine Comorbidity behavioral disciplines and activities Internal medicine mental disorders medicine Humans Child Aged Retrospective Studies Psychiatric Status Rating Scales Retrospective cohort study Middle Aged Cyclohexanols medicine.disease Clinical trial Psychiatry and Mental health Treatment Outcome Delayed-Action Preparations Anesthesia Concomitant Female Psychology Reuptake inhibitor Selective Serotonin Reuptake Inhibitors Anxiety disorder medicine.drug |
| Zdroj: | The Journal of Clinical Psychiatry. 64:546-550 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.v64n0508 |
| Popis: | Background While selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment of obsessive-compulsive disorder (OCD), approximately 40% of patients fail to respond to SSRIs. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that might be effective in the treatment of OCD, even among those who have failed previous SSRI trials. Method Thirty-nine patients who met DSM-IV criteria for OCD, including 29 who were resistant to prior SRI treatment trials, were treated with venlafaxine in an open, naturalistic fashion. Improvement was assessed using the Clinical Global Impressions-Improvement scale. Results Of 39 patients treated with venlafaxine, 27 (69.2%) were rated as sustained treatment responders. Of the 29 patients who did not respond to 1 or more previous SRI trials, 22 (75.9%) were rated as having sustained response to treatment. Mean dose of venlafaxine was 232.2 mg/day (range, 37.5-375 mg/day), and it was generally well tolerated. Conclusion Venlafaxine may be beneficial to individuals with OCD, including those who have not responded to prior SSRI trials. However, these findings must be interpreted with caution, as the study is limited by its open, retrospective nature and its inclusion of patients with comorbid diagnoses and patients on concomitant medications. Prospective, controlled trials with a more homogeneous patient population are needed to replicate these preliminary findings. |
| Databáze: | OpenAIRE |
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