Biomechanical Properties of the Cornea Measured With the Dynamic Scheimpflug Analyzer in Young Healthy Adults
| Autor: | Eung Kweon Kim, Jin-Young Choi, Byoung Jin Ha, Ha Yan Kim, Kyoung Yul Seo, Tae Im Kim, Hun Lee, David Sung Yong Kang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Intraocular pressure medicine.medical_specialty Percentile genetic structures Scheimpflug principle Spearman's rank correlation coefficient Biomechanical Phenomena Cornea Tonometry Ocular Young Adult 03 medical and health sciences 0302 clinical medicine Reference Values Ophthalmology Humans Medicine Prospective Studies Intraocular Pressure business.industry Ultrasound Regression analysis eye diseases Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Regression Analysis Female sense organs business |
| Zdroj: | Cornea. 36:53-58 |
| ISSN: | 0277-3740 |
| DOI: | 10.1097/ico.0000000000001001 |
| Popis: | Purpose To investigate the biomechanical properties of the cornea using the dynamic Scheimpflug analyzer in young healthy adults. Methods This prospective cross-sectional population study included 944 eyes of 472 participants aged 20 to 40 years. Participants underwent ophthalmic investigations, including evaluation of biomechanical properties of the cornea using the dynamic Scheimpflug analyzer, manifest refraction, and measurements of keratometric values by autokeratometry, intraocular pressure (IOP) by noncontact tonometer, central corneal thickness (CCT) by ultrasound, and white-to-white distance by Scheimpflug tomography. Statistical analyses included determination of the reference interval with a bootstrapping method, linear quantile mixed-effects model, and Spearman correlation analysis between the corneal biomechanical parameters and other variables (age, manifest refraction spherical equivalent, CCT, IOP, white-to-white, and keratometric values). Results The 90% CIs of all corneal biomechanical parameters demonstrated that the ranges of the 90% CIs for the reference data were almost identical with and without bootstrapping. Quantile regression to determine the fifth, 50th, and 95th percentiles of each corneal biomechanical parameter supported the findings from the nonparametric method with the 90% CIs. Correlation analysis showed significant correlations between the parameters and variables, but there was a relatively high Spearman correlation coefficient in the case of the correlations with the CCT and IOP. Conclusions Using data from a large population of young healthy adults, we developed a database of normal values for multiple corneal biomechanical parameters obtained from the dynamic Scheimpflug analyzer. We conclude that the biomechanical properties of the cornea are influenced by the CCT and IOP. |
| Databáze: | OpenAIRE |
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