Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy
| Autor: | Aidnag Z. Diaz, Jacob Y. Shin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Kaplan-Meier Estimate Astrocytoma Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Adjuvant therapy Chi-square test Humans Karnofsky Performance Status Young adult Aged Aged 80 and over Brain Neoplasms Proportional hazards model business.industry Age Factors Middle Aged Prognosis medicine.disease Surgery Neurology Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Concomitant Regression Analysis Female Radiotherapy Adjuvant Neurology (clinical) business Adjuvant 030217 neurology & neurosurgery Anaplastic astrocytoma |
| Zdroj: | Journal of Neuro-Oncology. 129:557-565 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-016-2210-1 |
| Popis: | To determine the receipt and impact of adjuvant therapy on overall survival (OS) for anaplastic astrocytoma (AA). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan-Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 4807 patients with AA diagnosed from 2004 to 2013 who underwent surgery were identified. 3243 (67.5 %) received adjuvant chemoRT, 525 (10.9 %) adjuvant radiotherapy (RT) alone, 176 (3.7 %) adjuvant chemotherapy alone and 863 (18.0 %) received no adjuvant therapy. Patients were more likely to receive adjuvant chemoRT if they were diagnosed in 2009-2013 (p = 0.022), were ≤ 50 years (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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