Prevalence and risk factors for low bone mineral density in antiretroviral therapy-naive HIV-infected young men
| Autor: | Julien Paccou, N. Viget, Elodie Drumez, Bernard Cortet, Olivier Robineau |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty HIV Infections 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Bone Density Risk Factors Hiv infected Internal medicine Prevalence medicine Humans Reference population 030212 general & internal medicine Femoral neck Bone mineral business.industry Antiretroviral therapy Bone Diseases Metabolic Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Anti-Retroviral Agents Cohort Lumbar spine business Hormone |
| Zdroj: | Médecine et Maladies Infectieuses. 48:442-448 |
| ISSN: | 0399-077X |
| DOI: | 10.1016/j.medmal.2018.02.009 |
| Popis: | Objective We aimed to investigate the prevalence of low bone mineral density (BMD) and associated factors in antiretroviral therapy (ART)-naive HIV-infected young men. Methods In this cross-sectional study, dual-energy X-ray absorptiometry (DXA) was used to measure BMD. BMD at the lumbar spine, total hip and femoral neck sites was expressed as a Z-score (number of standard deviations away from the mean in an age, race and sex-matched reference population). Low BMD was defined as Z-scores ≤ −2 at any of the three sites. The prevalence of low BMD was evaluated at the lumbar spine, total hip and femoral neck sites, as were risk factors associated with Z-scores. Results The study cohort comprised 49 men, of whom 87.8% were white. Mean age was 31.6 (± 7.7) years and mean BMI was 22.7 (± 4.0) kg/m2. Half of patients (51.0%) were current smokers. The prevalence of low BMD was 24.5% [95% CI, 13.3–38.9]. Low estradiol levels and low BMI were associated with low Z-scores at each skeletal site, whereas current smoking and high IGF1 levels were associated with low Z-scores at the lumbar spine site. Among the HIV-related factors, low CD4+ cell count was associated with low Z-scores at the lumbar spine site. Conclusions We observed a high prevalence of low BMD in our ART-naive cohort of young men. Risk factors associated with low Z-scores were those usually observed in HIV-infected individuals (low BMI, current smoking and CD4+ cell count) or linked to endocrine hormone levels (estradiol, IGF-1). |
| Databáze: | OpenAIRE |
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