Polymorphisms and haplotypes in VDR gene are associated with female idiopathic infertility
| Autor: | Gorana Stamenković, Jelena Djurovic, Oliver Stojkovic, Jelena Todorovic, Natasa Aleksic |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Vitamin medicine.medical_specialty VDR gene Idiopathic infertility Calcitriol receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Gene Transcription factor Unexplained infertility Polymorphism Genetic business.industry Haplotype Obstetrics and Gynecology DNA polymorphisms General Medicine Reproductive failure 030104 developmental biology Endocrinology Haplotypes Reproductive Medicine chemistry Case-Control Studies Receptors Calcitriol Female business Infertility Female Idiopathic female infertility |
| Zdroj: | Human Fertility |
| ISSN: | 1742-8149 1464-7273 |
| DOI: | 10.1080/14647273.2018.1515503 |
| Popis: | Unexplained infertility refers to the absence of a definable cause of reproductive failure. Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy. We conducted a case-control study to examine the association of polymorphisms in VDR gene with reproductive success. DNA from 117 female patients with unexplained infertility and 130 fertile controls was isolated from peripheral blood and VDR genotypes (FokI, BsmI, ApaI and TaqI) were detected by PCR-RFLP. Haplotypes were determined using Haploview software. Our results show significant association of FokI and BsmI polymorphisms with infertility (p < 0.05). The haplotype analysis confirmed strong linkage disequilibrium between closely positioned BsmI, ApaI and TaqI polymorphisms. Two haplotypes were associated with infertility: (i) hapl... |
| Databáze: | OpenAIRE |
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