Riser’s reflux - an eye-opening experience
Autor: | Ronnie Fass, Tomas Navarro-Rodriguez, Larissa M. Allen, Bridget Moty, Jeannette Powers, Stuart F. Quan, Isaac Malagon, Anita Gasiorowska, Marcia R. Willis, Choo Hean Poh |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Esophageal pH Monitoring Time Factors Physiology Severity of Illness Index Gastroenterology Surveys and Questionnaires Internal medicine Severity of illness Electric Impedance Humans Medicine Aged Morning Aged 80 and over Chi-Square Distribution medicine.diagnostic_test Endocrine and Autonomic Systems business.industry digestive oral and skin physiology Reflux Heartburn Actigraphy Middle Aged digestive system diseases Circadian Rhythm Anesthesia Ph testing Gastroesophageal Reflux Female medicine.symptom Sleep business Esophageal pH monitoring Chi-squared distribution |
Zdroj: | Neurogastroenterology & Motility. 22:387-394 |
ISSN: | 1365-2982 1350-1925 |
DOI: | 10.1111/j.1365-2982.2009.01446.x |
Popis: | Background Patients with gastro-oesophageal reflux disease (GORD) commonly report waking up in the morning with a sour or bitter taste in their mouth. The aim of the study was to compare the prevalence and frequency of acid reflux events prior to and immediately after awakening from sleep in the morning between GORD patients and normal subjects. Methods Thirty-nine patients with heartburn at least three times a week and abnormal pH test and nine healthy controls were included. All subjects were evaluated by demographic and GORD Symptom Checklist questionnaires. Subjects underwent pH testing concomitantly with actigraphy. A novel technology that simultaneously integrates raw actigraphy and pH monitoring data was utilized to determine the presence, frequency, and characteristics of acid reflux events prior to (up to 1 h) and immediately after (10 and 20 min) awakening from sleep in the morning. Key Results Nineteen (48.7%) of the GORD patients had an acid reflux event within the first 20 min after awakening from sleep in the morning as compared to only seven (17.9%) during the hour prior to awakening. Within the first 10 and 20 min after awakening, patients had a total of 32 and 60 acid reflux events, respectively, as compared to 14 during the 1 h prior to awakening (P < 0.05). None of the healthy control patients demonstrated any reflux events during these three studied periods (P < 0.001). Conclusions & Inferences Risers reflux is very common among GORD patients and possibly may explain reports of early-morning GORD symptoms. |
Databáze: | OpenAIRE |
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