Feasibility and Diagnostic Performance of Voxelwise Computed Diffusion-Weighted Imaging in Breast Cancer
| Autor: | Endong Chen, Qiong Ye, Shuxin Ye, Jiance Li, Jiejie Zhou, Liang Zhao, Qinyuan Cheng, Meihao Wang, Huazhi Xu, Min-Ying Su |
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| Rok vydání: | 2019 |
| Předmět: |
Intraclass correlation
Image quality Biopsy Image Processing Contrast Media Signal-To-Noise Ratio Medical and Health Sciences 030218 nuclear medicine & medical imaging 0302 clinical medicine Computer-Assisted Engineering Image Processing Computer-Assisted Medicine Breast Stage (cooking) Cancer Observer Variation education.field_of_study screening and diagnosis breast cancer diagnosis Signal Processing Computer-Assisted Middle Aged computed diffusion weighted imaging voxelwise cDWI (vcDWI Detection Nuclear Medicine & Medical Imaging 030220 oncology & carcinogenesis Area Under Curve Physical Sciences Biomedical Imaging Female medicine.symptom Algorithms 4.2 Evaluation of markers and technologies Adult Adolescent Population Breast Neoplasms Article Lesion 03 medical and health sciences Young Adult Clinical Research Breast Cancer diffusion weighted imaging Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging education Retrospective Studies Aged Receiver operating characteristic business.industry Diffusion Magnetic Resonance Imaging ROC Curve Signal Processing Feasibility Studies business Nuclear medicine Diffusion MRI |
| Zdroj: | Journal of magnetic resonance imaging : JMRI, vol 49, iss 6 J Magn Reson Imaging |
| Popis: | BACKGROUND Conventional diffusion-weighted imaging (DWI) with high b-values may improve lesion conspicuity, but with a low signal intensity and thus a low signal-to-noise ratio (SNR). The voxelwise computed DWI (vcDWI) may generate high-quality images with a strong lesion signal and low background. PURPOSE To evaluate the feasibility and diagnostic performance of vcDWI. STUDY TYPE Retrospective. POPULATION In all, 67 patients with 72 lesions, 33 malignant and 39 benign. FIELD STRENGTH/SEQUENCE 3T, including T2 /T1 , DWI with two b-values, and dynamic contrast-enhanced MRI (DCE-MRI). ASSESSMENT Computed DWI (cDWI) with high b-values of 1500, 2000, 2500 s/mm2 (cDWI1500 , cDWI2000 , cDWI2500 ) and vcDWI were generated from measured DWI (mDWI). The mDWI, cDWIs and vcDWI were evaluated by three readers independently to determine lesion conspicuity, background signal suppression, overall image quality using 1-5 rating scales, as well as to give BI-RADS scores. The mean apparent diffusion coefficient (ADC) value for each lesion was measured. STATISTICAL TESTS Agreement among the three readers was evaluated by the intraclass correlation coefficient. Receiver operating characteristic (ROC) analysis was performed to compare the diagnostic performance based on reading of mDWI, cDWIs, vcDWI, and the measured ADC values. RESULTS vcDWI provided the best lesion conspicuity compared with mDWI and cDWIs (P |
| Databáze: | OpenAIRE |
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