Local and global functions of Timeless and Tipin in replication fork protection
| Autor: | Eishi Noguchi, Adam R. Leman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
fork pausing
DNA Replication DNA re-replication Chromosomal Proteins Non-Histone Tipin Cell Cycle Proteins Review Saccharomyces cerevisiae Timeless Chromatids Swi1 Pre-replication complex Csm3 Swi3 Replication fork protection DNA replication factor CDT1 checkpoint Replication fork protection complex Control of chromosome duplication Minichromosome maintenance Tof1 Schizosaccharomyces difficult-to-replicate sites Humans Fork protection complex Molecular Biology Genetics biology DNA replication Nuclear Proteins DNA Cell Biology Telomere cohesion genome integrity FPC biology.protein Developmental Biology |
| Zdroj: | Cell Cycle |
| ISSN: | 1551-4005 1538-4101 |
| Popis: | The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course of every cell cycle. This accomplishment is remarkable considering that the conditions for DNA replication are rarely ideal. The replication machinery encounters a variety of obstacles on the chromosome, including damaged template DNA. In addition, a number of chromosome regions are considered to be difficult to replicate owing to DNA secondary structures and DNA binding proteins required for various transactions on the chromosome. Under these conditions, replication forks stall or break, posing grave threats to genomic integrity. How does the cell combat such stressful conditions during DNA replication? The replication fork protection complex (FPC) may help answer this question. Recent studies have demonstrated that the FPC is required for the smooth passage of replication forks at difficult-to-replicate genomic regions and plays a critical role in coordinating multiple genome maintenance processes at the replication fork. |
| Databáze: | OpenAIRE |
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