Contrast enhanced computed tomography assessment of superficial inguinal sentinel lymph node metastasis in canine mammary gland tumors
| Autor: | Christina Soultani, Kyriakos Chatzimisios, Theodoros Theodoridis, Georgios Kazakos, Tatiani Soultana M. Ilia, Lysimachos G. Papazoglou, Massimo Vignoli, Ioanna Tragoulia, Michail Patsikas, Paraskevi Papadopoulou, Vasileia Angelou, Georgia M. Ilia, Maria Karagiannopoulou, Stavros Tselepidis, Monique Mayer |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
040301 veterinary sciences
media_common.quotation_subject Mammary gland Sentinel lymph node Contrast Media Iopamidol 030218 nuclear medicine & medical imaging Metastasis 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs Hounsfield scale medicine Cutoff Contrast (vision) Animals Dog Diseases media_common Retrospective Studies General Veterinary business.industry Sentinel Lymph Node Biopsy Lymphography 04 agricultural and veterinary sciences medicine.disease medicine.anatomical_structure Superficial inguinal lymph nodes Case-Control Studies Lymphatic Metastasis Lymph Nodes Sentinel Lymph Node business Nuclear medicine Tomography X-Ray Computed medicine.drug |
| Popis: | Mammary gland neoplasms are predominant in dogs. However, sentinel lymph node (SLN) status assessment criteria have not been established for these cases. In this retrospective, secondary analysis, diagnostic case control study, CT images of 65 superficial inguinal SLNs were obtained before and 1, 3, 5, and 10 min after intravenous administration of contrast agent (iopamidol 370 mgI/mL). The presence and degree of postcontrast enhancement were assessed, by means of the median absolute density value and the maximum absolute density value at any time point in the center and in the periphery of each SLN measured in Hounsfield units (HU), before and after contrast agent administration. These values were compared with histopathological findings postsurgical excision. Receiver operating characteristic analysis was conducted. The absolute density values ranged widely at each time point and within each group of nodes (negative, positive, control group). At all time points, the median density value in the center and in the periphery was significantly higher in metastatic than in non-metastatic SLNs (P ≤ .014). Among the parameters tested, the median absolute density value measured in the periphery of the SLN 3 min after injection showed the highest sensitivity, specificity, and accuracy (AUC) (87.5%, 82.1%, and 92.1% respectively), with a cutoff value of 50.9 HU. The maximum absolute density value at any time point in the center and periphery of the SLNs was also significantly higher in metastatic SLNs compared to non-metastatic (P ≤ .001). With a cutoff value of 59.5 HU, the maximum absolute density value in the periphery of the SLN displayed high sensitivity and specificity (87.5% and 89.3%, respectively). The results of this study support the hypothesis that contrast enhanced CT imaging may aid in the assessment of SLN metastasis in dogs with mammary gland neoplasms. |
| Databáze: | OpenAIRE |
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