Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study
| Autor: | Jurij Hanžel, Barbara Eržen, Žiga Piletič, Mišo Šabovič, Martina Turk Veselič |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Brachial Artery Myocardial Infarction Infarction Pilot Projects Pulse Wave Analysis Vascular Stiffness Double-Blind Method Clinical Research Internal medicine medicine Humans Myocardial infarction Fluvastatin Pulse wave velocity Reactive hyperemia business.industry General Medicine Middle Aged medicine.disease Carotid Arteries Blood pressure Valsartan cardiovascular system Arterial stiffness Cardiology Drug Therapy Combination Endothelium Vascular business Blood Flow Velocity medicine.drug |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.908967 |
| Popis: | BACKGROUND We tested the concept of improving arterial wall characteristics by treatment with a very low-dose combination of fluvastatin and valsartan (low-flu/val) in stable, post-myocardial infarction (MI) patients. MATERIAL AND METHODS We enrolled 36 post-MI middle-aged males in the treatment (n=20) or control (n=16) group receiving low-flu/val (10 mg/20 mg) or placebo, respectively. The parameters of endothelial function (flow-mediated dilatation (FMD), reactive hyperemia index), and arterial stiffness (carotid-femoral pulse wave velocity (cf-PWV), local carotid PWV, and beta stiffness coefficient) were measured before and after 30 days of therapy, and 10 weeks later. RESULTS Treatment with low-flu/val improved FMD from 3.1±1.3% to 4.8±1.5% (p |
| Databáze: | OpenAIRE |
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