Interleukin-4 C-590T polymorphism has no role in coronary artery bypass surgery
| Autor: | Abdul K. Deiraniya, Nizar Yonan, N. Khasati, Mohamad N. Bittar |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Time Factors Genotype Coronary Artery Disease 030204 cardiovascular system & hematology Gastroenterology law.invention 03 medical and health sciences Coronary artery bypass surgery 0302 clinical medicine Gene Frequency law Internal medicine medicine Genetic predisposition Cardiopulmonary bypass Humans Prospective Studies Coronary Artery Bypass Prospective cohort study Allele frequency Interleukin 4 Polymerase chain reaction Aged Cardiopulmonary Bypass Polymorphism Genetic business.industry General Medicine Middle Aged Phenotype Treatment Outcome 030228 respiratory system Elective Surgical Procedures Cardiology Surgery Female Interleukin-4 Cardiology and Cardiovascular Medicine business |
| Zdroj: | Asian cardiovascularthoracic annals. 15(3) |
| ISSN: | 1816-5370 |
| Popis: | Interleukin-4 exerts anti-inflammatory effects through decreased macrophage production of tumor necrosis factor-α and interleukin-1ß. We investigated genetic predisposition in the interleukin-4 response to coronary revascularization and studied the association between C-590T polymorphism, interleukin-4 levels, and outcome of surgery. DNA was obtained from 96 consecutive patients undergoing elective coronary revascularization. Patients were genotyped for interleukin-4 C-590T polymorphism using a sequence-specific primer polymerase chain reaction. Interleukin-4 levels were measured using an enzyme-linked immunosorbent assay in serum samples taken 3 hr postoperatively. The frequency of interleukin-4 C-590T genotypes CC, CT, and TT was 33.3%, 27.1%, and 39.6%, respectively. Patients with the TT genotype had significantly higher circulating levels of interleukin-4 (3.4 ± 4.6 pg·mL−1) postoperatively compared to CC (2.5 ± 0.1 pg·mL−1) and CT (2.7 ± 0.5 pg·mL−1) genotypes. Interleukin-4 C-590T polymorphism is the main determinant of postoperative interleukin-4 levels. The TT genotype is the highest producer of interleukin-4. Neither the genotype nor the serum levels seem to play any role in recovery from coronary artery bypass surgery. |
| Databáze: | OpenAIRE |
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