Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors
| Autor: | Pierre Adumeau, René Raavé, Milou Boswinkel, Sandra Heskamp, Hans J. C. T. Wessels, Alain J. van Gool, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Victor Goncalves, Franck Denat |
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| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Radioisotopes Immunoconjugates Organic Chemistry Biomedical Engineering Pharmaceutical Science Bioengineering Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] All institutes and research themes of the Radboud University Medical Center Cell Line Tumor Neoplasms Positron-Emission Tomography Humans Tissue Distribution Zirconium Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19] Biotechnology Fluorescent Dyes |
| Zdroj: | Bioconjugate Chemistry, 33, 3, pp. 530-540 Bioconjugate Chemistry, 33, 530-540 |
| ISSN: | 1520-4812 1043-1802 |
| Popis: | Because positron emission tomography (PET) and optical imaging are very complementary, the combination of these two imaging modalities is very enticing in the oncology field. Such bimodal imaging generally relies on imaging agents bearing two different imaging reporters. In the bioconjugation field, this is mainly performed by successive random conjugations of the two reporters on the protein vector, but these random conjugations can alter the vector properties. In this study, we aimed at abrogating the heterogeneity of the bimodal imaging immunoconjugate and mitigating the impact of multiple random conjugations. A trivalent platform bearing a DFO chelator for |
| Databáze: | OpenAIRE |
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