Sulfobacins A and B, Novel von Willebrand Factor Receptor Antagonists. I. Production, Isolation, Characterization and Biological Activities
| Autor: | Tsutomu Kamiyama, Tomoko Satoh, Takayuki Umino, Michiko Shirane, Sayoko Sawairi, Shoichi Ohshima, Kazuteru Yokose |
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| Rok vydání: | 1995 |
| Předmět: |
Stereochemistry
Receptors Cell Surface Platelet Membrane Glycoproteins Flavobacterium chemistry.chemical_compound Von Willebrand factor hemic and lymphatic diseases Drug Discovery Aurintricarboxylic acid Animals Humans Platelet Paraformaldehyde Receptor Pharmacology Molecular Structure biology Biological activity Molecular biology Agglutination (biology) Alkanesulfonic Acids chemistry Sephadex biology.protein Cattle circulatory and respiratory physiology |
| Zdroj: | The Journal of Antibiotics. 48:924-928 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.48.924 |
| Popis: | Sulfobacins A and B, novel von Willebrand factor (vWF) receptor antagonists, have been isolated from the culture broth of Chryseobacterium sp. (Flavobacterium sp.) NR 2993 by ethyl acetate extraction, and by Sephadex LH-20 and silica gel column chromatographies. The physico-chemical properties of the sulfobacins indicate that their structures are completely different from that of aurintricarboxylic acid, the one known vWF receptor antagonist. Sulfobacins A and B inhibit the binding of vWF to its receptor with IC50S of 0.47 and 2.2 microM, respectively. Sulfobacin A also inhibits ristocetin-induced agglutination in human platelets fixed with paraformaldehyde with an IC50 of 0.58 microM. |
| Databáze: | OpenAIRE |
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