Activity of siderophores against drug-resistant Gram-positive and Gram-negative bacteria
| Autor: | Ramprasad B. Pal, Karuna Gokarn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
xenosiderophores
0301 basic medicine Siderophore Gram-negative bacteria medicine.drug_class Antibiotics medicine.disease_cause Microbiology 03 medical and health sciences Minimum inhibitory concentration Ampicillin medicine Pharmacology (medical) iron-chelation Original Research Pharmacology exochelin MS biology Chemistry Pathogenic bacteria deferoxamine B biology.organism_classification Acinetobacter baumannii 030104 developmental biology Infectious Diseases Infection and Drug Resistance Bacteria medicine.drug |
| Zdroj: | Infection and Drug Resistance |
| ISSN: | 1178-6973 |
| Popis: | Karuna Gokarn,1,2 Ramprasad B Pal1 1Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, 2Caius Research Laboratory, St Xavier’s College, Mumbai, India Abstract: Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores – exochelin-MS and deferoxamine-B– were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers – Pseudomonas aeruginosa and Acinetobacter baumannii– by disc diffusion, micro-broth dilution, and turbidimetric growth assays. The drug-resistant isolates were inhibited by the synergistic activity of siderophores and antibiotics. Minimum inhibitory concentration of exochelin-MS+ampicillin for different isolates was between 0.05 and 0.5mg/mL. Minimum inhibitory concentration of deferoxamine-B+ampicillin was 1.0 mg/mL and greater. Iron-chelation therapy could provide a complementary approach to overcome drug resistance in pathogenic bacteria. Keywords: iron-chelation, xenosiderophores, exochelin MS, deferoxamine B |
| Databáze: | OpenAIRE |
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