Synthesis and purification of sodium [11C]benzoate for physiological and metabolic studies: evaluation in a tumor-bearing dog
| Autor: | P.B. Zanzonico, R. Lee, M.B. Winstead, R.E. Bigler, J.K. Jacobsen, Robert E. Reiman, B. Schmall, J.R. Dahl, P.S. Conti |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Sodium No carrier added Rectilinear scanner Grignard reaction chemistry.chemical_element Phenylmagnesium bromide Kidney Benzoates chemistry.chemical_compound Dogs Left femur Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Carbon Radioisotopes Radionuclide Imaging Osteosarcoma Femoral Neoplasms Radiochemistry Benzoic Acid medicine.disease Endocrinology chemistry Sodium benzoate Sarcoma |
| Zdroj: | International Journal of Nuclear Medicine and Biology. 11:179-183 |
| ISSN: | 0047-0740 |
| DOI: | 10.1016/0047-0740(84)90058-5 |
| Popis: | Sodium benzoate labeled with the cyclotron produced, positron emitting radioisotope 11C ( t 1 2 = 20.4 min ) has been investigated as a potential agent for renal and tumor visualization using γ-scintigraphy. Sodium [11]benzoate was prepared by the Grignard reaction of phenylmagnesium bromide and 11C-CO2 with no carrier added. A dog bearing an osteogenic sarcoma in the head of the left femur was studied using the High Energy Gamma (HEG) rectilinear scanner at the Sloan-Kettering Institute following i.v. administration of no-carrier-added sodium [11C]benzoate. The high-contrast image of the kidneys in this dog demonstrates the potential usefulness of [11C]benzoate as a renal scanning agent. Visualization of a canine osteogenic sarcoma, in addition to a human brain tumor reported in a previous study, suggests that [11C]benzoate should be further evaluated as a tumor imaging agent. |
| Databáze: | OpenAIRE |
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