Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania
| Autor: | Michael Alifrangis, Edwin Liheluka, Paul M. Hayuma, Gerald Misinzo, Daniel T. R. Minja, Christian W. Wang, Vito Baraka, John Lusingu, Rashid A. Madebe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Plasmodium falciparum RC955-962 Anaemia Infectious and parasitic diseases RC109-216 Parasitemia Tanzania Asymptomatic Young Adult Internal medicine Arctic medicine. Tropical medicine parasitic diseases Submicroscopic parasitaemia medicine Humans Malaria Falciparum Child Asymptomatic Infections Rapid diagnostic test biology business.industry Research Asymptomatic infection Infant Newborn Infant Anemia North-eastern Tanzania biology.organism_classification medicine.disease Dried blood spot Cross-Sectional Studies Infectious Diseases Parasitology Child Preschool Tropical medicine Female medicine.symptom business Malaria |
| Zdroj: | Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021) Malaria Journal Hayuma, P M, Wang, C W, Liheluka, E, Baraka, V, Madebe, R A, Minja, D T R, Misinzo, G, Alifrangis, M & Lusingu, J P A 2021, ' Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania ', Malaria Journal, vol. 20, 424 . https://doi.org/10.1186/s12936-021-03952-3 |
| ISSN: | 1475-2875 |
| Popis: | Background Asymptomatic malaria infections largely remain undetected and act as a reservoir for continuous transmission. The study assessed the prevalence of submicroscopic asymptomatic malaria infections and anaemia in two rural low (300 m above sea level) and highland (700 m asl) settings of Korogwe District north-eastern Tanzania. Methods A cross-sectional malariometric survey involving individuals aged 0–19 years was conducted in June 2018 in the two rural villages. Venous blood was collected from eligible study participants for estimation of haemoglobin level, detection of malaria by rapid diagnostic test (RDT), quantification of malaria parasitaemia by microscopy, as well as dried blood spot (DBS) for determining submicroscopic infections by PCR targeting the small subunit of the ribosomal ribonucleic acid (ssrRNA) of human Plasmodium. Results Out of 565 individuals tested, 211 (37.3%) were malaria positive based on RDT, whereas only 81 (14.3%) were positive by microscopy. There was no significant difference in the prevalence between the highland and the lowland village, p = 0.19 and p = 0.78 microscopy and RDT, respectively. Three out of 206 (1.5%) RDT/microscopy negative samples were P. falciparum positive by PCR. Of the 211 RDT and 81 microscopy positive, 130 (61.6%) and 33 (40.7%), respectively, were defined as being asymptomatic. Of the 565 individuals, 135 (23.9%) were anaemic (haemoglobin Conclusions Asymptomatic malaria is associated with an increased risk of having anaemia in the study communities. The findings highlight the need for targeted interventions focusing on asymptomatic infections which is an important risks factor for anaemia in the community and act as a source of continued transmission of malaria in the study area. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|